boronic acid is an organic compound with the chemical formula C5H4BClFNO2.
Nature:
-Appearance:(2-chloro-5-fluoro-4-pyridyl)boronic acid usually exists in the form of a colorless crystalline solid.
-Solubility: Soluble in some polar solvents, such as chloroform, dimethyl sulfoxide and dichloromethane. Slightly soluble in ethanol and methanol, insoluble in water.
Use:
-(br>) boronic acid is commonly used in the field of organic synthesis, as a drug intermediate or.
-As a ligand, it can form complexes with transition metals, and is often used to catalyze coupling reactions, such as Suzuki coupling reactions and Suzuki-Miyaura coupling reactions, to construct aromatic compounds.
-can also be used for the synthesis of drugs containing tetracycline structure.
Preparation Method:
- (Bi) The preparation of boronic acid can be achieved by the reaction of phenylboronic acid and 2-chloro-5-fluoropyridine. The two are mixed in a suitable solvent and heated to react, usually requiring the presence of a catalyst to obtain good yields.
Safety Information:
- (Note) boronic acid is relatively safe under correct operation, protective measures are still required, such as wearing appropriate protective gloves, eye protection and avoiding inhalation or ingestion.
-Avoid contact with the oxidant during handling and storage to prevent it from burning under the flame.
-Please operate under the guidance of experienced personnel and comply with relevant safety regulations.